Without Plexin-B1, Glial Net Closes in Around Plaques
The astrocytic receptor enforces cellular distancing among glia. Free from this constraint, they more ably contain plaques.
The astrocytic receptor enforces cellular distancing among glia. Free from this constraint, they more ably contain plaques.
A new study challenges this idea, finding that in mice, clearance of an injected dye slowed during sleep and anesthesia.
When the nuclear RNA-binding proteins NONO and SFPQ accumulate, adenosine-to-inosine editing of RNA runs amok. This spoils transcripts for axonal, synaptic, and mitochondrial proteins.
FDA qualification would streamline the use of plasma NfL to select asymptomatic carriers of pathogenic frontotemporal dementia mutations for enrollment in prevention trials.
Scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.
Equipped with ApoE3-Christchurch, microglia made short work of tau fibrils, and spewed fewer inflammatory cytokines.
Lecanemab will soon have maintenance dosing and subcutaneous formulations available; FDA advisory committee will consider donanemab June 10.
Astrocytes and microglia surround amyloid plaques in a glial net, but cell-to-cell distancing requirements keep them from compacting the aggregates with gusto. The distancing, it turns out, is enforced by Plexin-B1. Nixing this astrocyte receptor allowed glia to huddle tightly around plaques, mitigating damage to nearby synapses.
Besides forming protein inclusions in Parkinson’s and dementia with Lewy bodies, α-synuclein might cause other proteins to follow suit. In mutant synuclein neurons, and in synucleinopathy brain tissue, scientists found a new type of deposit—in the nucleus. RNA-binding proteins NONO and SFPQ form speckles. They disturb editing of mRNA. Edited transcripts stick to NONO/SFPQ aggregates, trapping them in the nucleus and precluding synaptic and mitochondrial protein production.
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